KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
|
Home
|
Kinexus
|
Contact
|
Credits
Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
TTK
All Species:
9.7
Human Site:
T355
Identified Species:
17.78
UniProt:
P33981
Number Species:
12
Phosphosite Substitution
Charge Score:
0.17
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P33981
NP_003309.2
857
97072
T355
L
I
I
T
D
S
I
T
L
K
N
K
T
E
S
Chimpanzee
Pan troglodytes
XP_001146752
857
97034
T355
L
I
I
T
D
S
I
T
L
K
N
K
T
E
S
Rhesus Macaque
Macaca mulatta
XP_001111082
778
87619
P316
L
V
V
A
G
S
K
P
S
G
N
D
S
C
E
Dog
Lupus familis
XP_539016
855
96614
T353
E
L
D
T
D
S
V
T
L
K
N
K
S
E
S
Cat
Felis silvestris
Mouse
Mus musculus
P35761
856
96192
I351
E
L
R
G
L
K
P
I
Q
T
I
Y
L
K
D
Rat
Rattus norvegicus
NP_001101642
835
94323
D333
I
Q
A
I
H
L
K
D
S
L
V
S
N
E
K
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001512474
935
104827
D358
K
S
L
E
T
T
D
D
S
T
L
T
L
K
N
Chicken
Gallus gallus
XP_419867
879
99691
N359
N
S
L
E
T
A
T
N
S
T
V
T
L
K
N
Frog
Xenopus laevis
NP_001082090
882
99060
S357
L
D
M
K
T
P
S
S
V
I
L
S
V
T
E
Zebra Danio
Brachydanio rerio
Q8AYG3
982
109993
G417
V
R
Y
A
E
L
K
G
I
E
D
P
E
D
A
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
XP_002301009
818
91361
L330
T
S
A
M
L
I
D
L
R
A
T
A
T
Q
P
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
NP_565160
777
86358
E315
P
A
S
T
N
D
P
E
V
R
V
K
E
T
D
Baker's Yeast
Sacchar. cerevisiae
P54199
764
86809
R302
S
N
N
G
S
Q
P
R
R
K
V
S
T
G
S
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.1
85.7
87.4
N.A.
74.3
76.9
N.A.
64.2
61
52.8
41.4
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
100
99.6
87.7
92.6
N.A.
84.8
85.6
N.A.
73.6
74.5
68.4
57
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
100
100
20
66.6
N.A.
0
6.6
N.A.
0
0
6.6
0
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
100
100
40
86.6
N.A.
13.3
13.3
N.A.
26.6
26.6
26.6
46.6
N.A.
N.A.
N.A.
N.A.
N.A.
Percent
Protein Identity:
23.1
N.A.
N.A.
22.9
22.7
N.A.
Protein Similarity:
40.2
N.A.
N.A.
42.3
44.5
N.A.
P-Site Identity:
6.6
N.A.
N.A.
13.3
20
N.A.
P-Site Similarity:
13.3
N.A.
N.A.
33.3
20
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
8
16
16
0
8
0
0
0
8
0
8
0
0
8
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
8
0
% C
% Asp:
0
8
8
0
24
8
16
16
0
0
8
8
0
8
16
% D
% Glu:
16
0
0
16
8
0
0
8
0
8
0
0
16
31
16
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
0
0
16
8
0
0
8
0
8
0
0
0
8
0
% G
% His:
0
0
0
0
8
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
8
16
16
8
0
8
16
8
8
8
8
0
0
0
0
% I
% Lys:
8
0
0
8
0
8
24
0
0
31
0
31
0
24
8
% K
% Leu:
31
16
16
0
16
16
0
8
24
8
16
0
24
0
0
% L
% Met:
0
0
8
8
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
8
8
8
0
8
0
0
8
0
0
31
0
8
0
16
% N
% Pro:
8
0
0
0
0
8
24
8
0
0
0
8
0
0
8
% P
% Gln:
0
8
0
0
0
8
0
0
8
0
0
0
0
8
0
% Q
% Arg:
0
8
8
0
0
0
0
8
16
8
0
0
0
0
0
% R
% Ser:
8
24
8
0
8
31
8
8
31
0
0
24
16
0
31
% S
% Thr:
8
0
0
31
24
8
8
24
0
24
8
16
31
16
0
% T
% Val:
8
8
8
0
0
0
8
0
16
0
31
0
8
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
8
0
0
0
0
0
0
0
0
8
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _